5-MeO-DMT aka 5-methoxy-N,N-dimethyltryptamine5-methoxy-dimethltrytamine is a psychedelic tryptamine. It can be found naturally in a few toad species and some cactus and other plants. It is a close relative of bufotenin and DMT. It is often the substance found in use by South American shamans/tribes in their rituals. | 
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The drug was synthesizes in 1936. It has traditionally been used in psychedelic snuff made from Virola bark resin. 5-Meo-DMT is also found in the venom of the Colorado River Toad which has recently been used for recreational purposes.
When purified 5-Meo_DMT is smoked, inhaled or injected and is active in as small a dose as 2mg. Effects occur within seconds after smoking or injecting or minutes otherwise. The experience is often described as near death trippy effects. The peak effect lasts for up to 30 minutes on average. Although similar to DMT its effects at not so visual. Some users complain of the drug inducing unpleasant nausea.
Erowid lists the following effects for smoked 5-MeO-DMT: Positiveimmersive experiences powerful "rushing" sensation radical perspective shifting profound life-changing spiritual experiences some people experience erotic / sensual enhancement occasional euphoria internal visions (actual visual effects not as common) journey into mind Neutralshort duration change in perception of time experience of "the void" lack of memory of experience muscle jerking, twitching, abnormal vocalizations unconsciousness / non responsiveness lasting 5-20 minutes dissociation Negativeoverly-intense experiences nausea sense of pressure in the body hard on the lungs to smoke difficulty integrating experiences fear, terror and panic dysphoria (bad feelings) fast onset and intensity can lead to problems if not prepared (dropped pipe, knocking things over, falling & hitting head, etc)
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